How is Sokal score calculated?
Sokal score, Euro score, and EUTOS score were calculated according to formulas given below at baseline. Sokal score = Exp [0.0116 × (age in years – 43.4) + 0.0345 × (spleen size – 7.51) + 0.188 9 ([platelet count ⁄ 700]2 – 0.563) + 0.0887 × (blast cell counts – 2.10)], where Exp is the exponential function [5].
What is sokal score?
One widely used prognostic index, the Sokal score, is calculated for patients aged 5-84 years by the following equation: Hazard ratio = exp 0.0116 (age – 43) + 0 .0345 (spleen size [cm below costal margin] – 7.5 cm) + 0.188 [(platelet count/700)2 – 0.563] + 0.0887 (% blasts in blood – 2.1)
Is CML a score?
Predicts survival of CML based on clinical and lab information. Use to predict prognosis at the time of CML diagnosis, before starting treatment. In the US, the Sokal Score can be used to determine risk and decide on therapy based on the NCCN guidelines for CML.
What is accelerated phase CML?
Accelerated Phase. In the accelerated phase, the number of immature blast cells has risen, and sometimes new chromosomal changes, in addition to the Ph chromosome, will occur. People with accelerated phase CML may have. More than 20 percent basophils (type of white blood cell) in the bloodstream.
What increases risk for leukemia?
People exposed to high doses of radiation (from the explosion of an atomic bomb, working in an atomic weapons plant, or a nuclear reactor accident) have a heightened risk of developing leukemia. Long-term exposure to high levels of solvents such as benzene — in the workplace, for example — is a known risk factor.
What is complete cytogenetic response?
A complete cytogenetic response means no (or less than 1% of) cells in the bone marrow have the Philadelphia chromosome. A partial cytogenetic response means between 1% and 35% of the cells in the bone marrow still have the Philadelphia chromosome.
What is a neoplasm of blood cells?
Myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets. Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time.
How long can a CML patient live?
Historically, the median survival of patients with CML was 3-5 years from the time of diagnosis. Currently, patients with CML have a median survival of 5 or more years.
Can you live a long life with chronic myeloid leukemia?
Generally for CML more than 70 out of 100 men (more than 70%) and almost 75 out of 100 women (almost 75%) will survive their leukaemia for 5 years or more after they are diagnosed. This is for all ages. Younger people tend to have a better outlook than older people.
How is cytogenetic response measured?
Cytogenetic response is based on the percentage of cells in a sample of your bone marrow that have the Philadelphia chromosome (and therefore are CML cells). This can be determined with either cytogenetics or FISH testing, both of which can find altered (mutated) chromosomes.