What does Granix do?
Granix (tbo-filgrastim) is a recombinant methionyl human granulocyte colony-stimulating growth factor (r-metHuG-CSF) used to reduce the duration of severe neutropenia in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile …
How fast does Granix work?
In cancer patients, the time to achieve a maximum absolute neutrophil count (ANCmax) was 3 to 5 days following administration of Granix, returning to baseline by 21 days after chemotherapy. Median Tmax of Granix is 4 to 6 hours and median half-life of Granix is 3.2 to 3.8 hours.
Is Granix and Zarxio the same thing?
Therefore, Granix covers a different on-label market than Neupogen. In contrast, Zarxio—approved in March 2015 and launched in September 2015—was the first drug approved through the biosimilar pathway, and it was approved for all 5 of the filgrastim indications.
What is the difference between Neulasta and Granix?
One important difference between Neulasta and Granix is how often the drugs are given to reduce the risk of infection during chemotherapy. Neulasta is given only once during each chemotherapy cycle. Granix, on the other hand, is given every day until the levels of neutrophils in your blood return to normal.
Is GRANIX a chemo drug?
Granix is used to reduce the duration of severe neutropenia, a lack of certain white blood cells caused by receiving chemotherapy with certain cancer medications. Granix is for use in adults and children who are least 1 month old.
Is GRANIX the same as Neupogen?
Granix is not technically considered a biosimilar to Neupogen because it was filed as a Biologics License Application since a biosimilars approval pathway had not been established at the time of FDA submission.
Is Granix a chemo drug?
What drug class is Granix?
Granix may be used alone or with other medications. Granix belongs to a class of drugs called Hematopoietic Growth Factors. It is not known if Granix is safe and effective in children younger than 1 month of age.
Is Granix a biologic?
How is G-CSF made?
Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).
Do all chemo patients get Neulasta?
Both the American Society of Clinical Oncology and the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology recommend the Neulasta injection with every chemo cycle to guard against a serious infection manifested by a high fever called febrile neutropenia.
Is Granix the same as Neupogen?