What is the cause of extramedullary hematopoiesis?

What is the cause of extramedullary hematopoiesis?

Extramedullary hematopoiesis occurs in severe chronic anemia, which can arise from deficiency disorders such as vitamin B12 or folate deficiency2 or from disorders affecting pluripotent stem cells.

Is it possible to have extramedullary hematopoiesis during adulthood?

Extramedullary hematopoiesis (EMH) implies the production of erythroid and myeloid progenitor cells outside of the bone marrow. EMH in adults is typically seen in patients with myeloproliferative neoplasms (MPNs) but its association also with other conditions, including thalassemia, has long been recognized1.

What are the causes of extramedullary hematopoiesis?

Normal blood production is maintained by the pluripotent stem cells. Extramedullary hematopoiesis occurs in severe chronic anemia, which can arise from deficiency disorders such as vitamin B12 or folate deficiency2 or from disorders affecting pluripotent stem cells.

What is extramedullary hematopoiesis (EMH)?

Attilio Orazi, Magdalena Czader, in Differential Diagnosis in Surgical Pathology (Second Edition), 2010 Extramedullary hematopoiesis (EMH) refers to the accumulation of hematopoietic precursor cells in the spleen A non-neoplastic EMH refers to the accumulation in the splenic red pulp of nonclonal hematopoietic precursor cells

Which radiographic findings are characteristic of extramedullary hematopoiesis?

Radiographic features. When involving an organ, extramedullary hematopoiesis causes visceromegaly occurring most often in the spleen (splenomegaly) and liver (hepatomegaly) and occasionally in the lymph nodes. Visceromegaly is best evaluated with ultrasound, CT or MRI. Lesions are typically hypermetabolic and are FDG-18 avid on PET-CT 4.

How is extramedullary hematopoiesis treated in nephrotic syndrome?

For treatment, giving radiotherapy on the involved site or excision of the mass or multiple blood transfusions to decrease extramedullary hematopoiesis can be done 4. 1. Choi H, David CL, Katz RL et-al. Case 69: extramedullary hematopoiesis.

How is visceromegaly diagnosed in extramedullary hematopoiesis?

When involving an organ, extramedullary hematopoiesis causes visceromegaly occurring most often in the spleen (splenomegaly) and liver (hepatomegaly) and occasionally in the lymph nodes. Visceromegaly is best evaluated with ultrasound, CT or MRI. Lesions are typically hypermetabolic and are FDG-18 avid on PET-CT 4.

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